SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW HETEROCYCLES CONTAINING NITROGEN AND SULPHUR

The literature survey on 1,2,4-Triazoles and chalcone derivatives revealed that they  are  endowed  with  wide  variety  of  biological  activities. During the present investigation newer series of chalcone derivatives S-4-(isonicotinamido)-5-(phenoxymethyl) – 4H-1,2,4 triazole-3-yl-3(-4-chlorophenyl) propanethioate (7a-7f) were synthesized by coupling  suitably  modified 1,2,4-Triazole nucleus with appropriate aryl aldehydes. The structures of the newly synthesized compounds were established by FTIR, ¹HNMR and Mass spectral analysis. All the compounds have been evaluated for in vitro antibacterial, antifungal and antitubercular activities. The compounds exhibited weak antibacterial activity only at higher concentrations. Whereas,  the  antifungal  activity  results  showed  that  few  of  the compounds  were  able to show moderate antifungal potency. The fungi used in the anti-microbial study were found to resistant to   the other compounds. The antitubercuar activity results were encouranging as the few compounds were able to possess growth inhibiting properties against the mycobacterium tested i.e the compounds 7b, 7e and 7f possessed the MIC as low as 6.25µg/ml. Even though the compounds failed to possess anti-bacterial and antifungal activity, it is quite interesting to note that most of the compounds were found to be promising biological agents as antitubercular.