SYNTHESIS AND BIOLOGICAL EVALUATION OF CHALCONES FROM 2-ACETYL-5-METHYLFURAN

The new chalcones of 2-acetyl-5-methylfuran derivatives are synthesized by reaction with various aromatic and hetero aromatic aldehydes using the method of aldol condensation. Characterization of these synthesized compounds performed with IR, ¹H NMR, physical characteristics like molecular mass, melting point and elemental analysis. The data related to structural characterization were given individually with antimicrobial activities.Characterization of these synthesized compounds performed with IR, ¹H NMR, physical characteristics like molecular mass, melting point and elemental analysis. The data related to structural characterization were given individually with antimicrobial activities. The literature suggests that chalcones are also useful intermediates for the synthesis of several chemical and pharmacological classes of therapeutic agents having heterocyclic structures in them. Also a number of chalcones with novel substituents synthesized, characterized and biologically evaluated for anti-microbial activity in our laboratory and significant outcome was observed. Thus various novel substituents for chalcone synthesis and QSAR studies will be a promising effort for development of better anti microbials with several significant biological activities.