SYNTHESIS AND BIOLOGICAL EVALUATION OF MARUMOSIDE A ISOLATED FROM MORINGA OLEIFERA AND ITS LIPID DERIVATIVESAbstract
In the present study, Marumoside A isolated from Moringa oleifera, a traditional medicinal plant, was synthesized for the first time using trichloroacetimidate donor as a key step. The aglycone 4-hydroxy phenylacetamide was prepared from 4-hydroxyphenyl acetic acid using oxallyl chloride and aqueous ammonia. The lipid derivatives of Marumoside A were synthesized using different fatty amines. The anti-inflammatory activity of the Marumoside A and its lipid derivatives was evaluated for the inhibition of TNF-α and IL-1β secretion levels. Among all the synthesized molecules, the oleoyl amine lipid (unsaturated) derivative showed significant inhibition of TNF-α and IL-1β secretion with IC50 value of 16.7 µM and 23.4 µM, respectively, when compared to Marumoside A and its saturated lipid derivatives. Further, the Marumoside A and its lipid derivatives also showed DPPH radical scavenging activity.
S. Vudhgiri, Prasad R. B. N., A. Kota, Poornachandra Y. , G. Kumar C, R. Sistla and R. C. Reddy Jala *
Centre for Lipid Research , CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.
31 August, 2015
15 October, 2015
06 December, 2015
01 February, 2016