SYNTHESIS AND BIOLOGICAL EVALUATION OF NEWER COUMARIN DERIVATIVES AS ANTIMICROBIAL AGENTSAbstract
For the synthesis of a series of novel Coumarin derivatives, an efficient and easy approach has been designed. 1H-NMR and Fourier Transformed Infrared (FTIR) characterize the structures of freshly synthesized compounds, which are then evaluated for antibacterial activity in vitro by calculating the zone of inhibition and minimum inhibitory concentration. The antibacterial and antifungal activity of 4-[(2-oxo-2-[5-(2-oxo-2H-chromen-3-yl)-1, 3-thiazol-2-yl] aminoethyl] amino] benzoic acid was comparable to that of ciprofloxacin and fluconazole. The reaming compounds had moderate to good activity.
Jayshree Kokat * and Bharat Jadhav
Department of Pharmaceutical Chemistry, Abasaheb Kakade College of B. Pharmacy, Bodhegaon, Ahmednagar, Maharashtra, India.
29 November 2021
13 January 2022
27 April 2022
01 August 2022