SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TETRAZOLE ANALOGUES OF FLAVONES AS ANTIMICROBIAL AGENTS
AbstractA series of flavones derivatives 11(a-j) have been synthesized and evaluated for their in-vitro antibacterial and antifungal activities. The antibacterial screening data showed that compounds with 4-methoxyphenyl (11c), 4-fluorophenyl (11d), and 2, 5-fluorophenyl (11h) substituent’s on tetrazole ring, showed the maximum activity against the organisms used. The antifungal screening revealed that a compound with 4-nitropheny (11g) on tetrazole ring exhibited the highest activity against A. niger and a compound with 4-methoxyphenyl (11c) group exhibited good activity against C. albicans.
Article Information
24
3444-3451
635 KB
277
English
IJPSR
Adki Nagaraj * and Gutha Nageswara Rao
Department of Chemistry, Telangana University, Dichpally, Nizamabad, Telangana, India.
nagarajadki@gmail.com
13 November 2022
24 December 2022
01 May 2023
10.13040/IJPSR.0975-8232.14(7).3444-51
01 July 2023
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