SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF CEPHALEXIN
AbstractCephalexin remain as one of the most versatile class of compounds against microbes and therefore, are useful substructures for further molecular exploration. A novel series of Schiff bases of cephalexin were synthesized. Thus condensation of 5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 7-[(amino phenyl acetyl) amino]-3-methyl-8-oxo, monohydrate with appropriate aldehydes afforded the Schiff bases. The purity of the compounds was determined by TLC. With elemental analysis and spectral data the structure of the synthesized compounds were elucidated. All the synthesized compounds were subjected for the screening of antimicrobial activity against 3 bacteria and two pathogenic fungi. Most of the synthesized compounds were found to possess moderate antibacterial and antifungal activity.
Article Information
44
1008-1014
833KB
1181
English
IJPSR
N.T. Arun* and B. Gowramma
Anna University – Bit Campus, Tiruchirappalli, Tamil Nadu – 620 024, India
arunyuvant@gmail.com
24 October, 2013
10 December, 2013
16 February, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).1008-14
01March2014
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