SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF CEPHALEXINAbstract
Cephalexin remain as one of the most versatile class of compounds against microbes and therefore, are useful substructures for further molecular exploration. A novel series of Schiff bases of cephalexin were synthesized. Thus condensation of 5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 7-[(amino phenyl acetyl) amino]-3-methyl-8-oxo, monohydrate with appropriate aldehydes afforded the Schiff bases. The purity of the compounds was determined by TLC. With elemental analysis and spectral data the structure of the synthesized compounds were elucidated. All the synthesized compounds were subjected for the screening of antimicrobial activity against 3 bacteria and two pathogenic fungi. Most of the synthesized compounds were found to possess moderate antibacterial and antifungal activity.
N.T. Arun* and B. Gowramma
Anna University – Bit Campus, Tiruchirappalli, Tamil Nadu – 620 024, India
24 October, 2013
10 December, 2013
16 February, 2014