SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PYRAZOLONES: A REVIEWAbstract
Heterocyclic compounds are acquiring more importance in recent years because of their pharmacological activities. Pyrazolones have a particular value due to their broad spectrum of biological activity and their wide ranging utility as synthetic tools in the design of various bioactive molecules. Pyrazolone is a five membered lactum ring, containing two nitrogen and one ketonic group in its structure. In addition, pyrazolones possess antimicrobial, antifungal, antimycobacterial, antibacterial, anti-inflammatory, antitumor, gastric secretion stimulatory, antidepressant and antifilarial activities. They also serve as precursors for dyes, pigments, pesticides and chelating agents, besides finding applications in the extraction and separation of various metal ions. The high therapeutic properties of the pyrazolone releted drugs have encouraged the medicinal chemists to synthesized a large number of novel chemotherapeutic agents. Numerous methods for the synthesis of pyrazolone and also their various structure reactions offer enormous scope in the field of medicinal chemistry. This articles aims to review the work reported, their chemistry and biological activities of pyrazolone during past years.
Poonam Gupta*, Jitendra K. Gupta and A. K. Halve
School of studies in Chemistry, Jiwaji University, Gwalior-474011, Madhya Pradesh, India
01 October, 2014
08 January, 2015
27 March, 2015
01 June, 2015