SYNTHESIS AND CHARACTERISATION OF BIO-INORGANIC TRANSITION METAL COMPLEXES DERIVED FROM NOVEL BIGINELLI ADDUCT COUPLED SCHIFF’S BASES

Novel Schiff base comprising 4-aminoantipyrine with Biginelli adducts of salicylaldehyde has been designed and synthesized. Solid metal complexes of this Schiff base with Ni(II), Zn(II), Cd(II) and Hg(II) metal ions were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, ESI mass, IR, NMR, and UV-Vis spectral studies. From the data, it has been observed that the complexes had the composition of ML₂ type, diamagnetic nature and a tetrahedral geometry around the metal ion except for Ni(II) complex which has square planar geometry. The Ligand and its complexes have been screened for their in-vitro antifungal and in-vitro antibacterial activities against the fungi i.e., Candida albicans, Aspergillus flavus, Penicillium spp., Aspergillus niger and Trichophyton and the gram-negative bacteria Escherichia coli, Vibrio spp., Pseudomonas aeroginosa, Vibrio para haemolytic, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp. and gram-positive bacteria Bacillus spp and Staphylococcus aureus. The in-vitro antimicrobial activities of these metal complexes found to be stronger than the ligand.