SYNTHESIS AND CHARACTERISATION OF IBUPROFEN, KETOPROFEN PRODRUG FOR TASTE MASKING USING β- CYCLODEXTRINAbstract
The Profens have indicated the gastrointestinal side effects due to the acidic moiety of the profen. The Profens are bitter in taste and it is omitted by mostly children. Therefore an attempt has been made to prepare the ester Prodrug using ethyl alcohol and butyl alcohol and its bitter taste is masked by using β-Cyclodextrin. The prepared prodrugs are characterised by melting point, UV and IR spectroscopy. The bitter taste intensity was evaluated using volunteers by comparison of test samples with standard solutions containing quinine at various concentrations.
G. Gnanarajan *, A. K. Gupta, Sandeep Negi and V. Juyal
Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology and Sciences, Patelnagar, Dehradun, Uttrakhand, India
18 May, 2010
17 July, 2010
24 August, 2010
15 September, 2010