SYNTHESIS AND CHARACTERIZATION OF GRAPHENE-USNIC ACID CONJUGATE MICROSPHERES AND ITS ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUSAbstract
In response to the spacious propagation of bacterial contamination stimulated by pathogens, the evolution of novel therapeutics with eminent antibacterial action is of avid concern. When the skin unity is ruptured accidentally or intentionally, its natural defenses will thus be vitiated, and topical medication may be prescribed. Topical medicaments are designed to either obliterate or inhibit the augmentation of pathogenic microorganism and can be consumed for both prophylaxes as well as treatment of superficial infection. Here is a novelize graphene-usnic acid conjugate was developed by way of a mere non-covalent process, and the loading and release demeanor of usnic acid on graphene were investigated. An effective loading of usnic acid on graphene prevailed at the initial usnic acid assiduousness of 300 mg/ml. The developed conjugate was embedded into biocompatible Eudragit polymers to formulate topically active microspheres. Formulated microspheres were characterized by FTIR, TGA, and graphene. Antibacterial activity was studied by the broth dilution method. Results disclosed that amalgamation of graphene and usnic acid had enhanced antibacterial activity against pathogen S. aureus. The outcomes-focused potential of formulated graphene-based microspheres for effective management of topical skin bugs and shed light on application of carbon allotrope graphene nanoplatelets in the arena of biomedicine.
S. Pandey *, S. K. Misra and N. Sharma
Mahatma Gandhi Institute of Pharmacy 1, Junabganj, Lucknow, Uttar Pradesh, India.
18 June 2018
16 August 2018
31 August 2018
01 February, 2019