SYNTHESIS AND CHARACTERIZATION OF PVA BASED POLY (ACRYLIC ACID – CO – ACRYLAMIDE) SUPER POROUS HYDROGELS COMPOSITESAbstract
The aspiration of the coeval cramming is connate with the entirety of second generation Super Porous Hydrogel Composites (SPHCs) with polyvinyl alcohol as a melded material. Conglomerates were unified by proving gas fanning approach. For coalescence, 50% Acrylamide solution (AM) and 50% Acrylic Acid solution (AA) were used as a monomer, 2.5% N, N’-methylene bisacrylamide (BIS) as a cross linker, 20% Ammonium Per Sulphate (APS) and 20% N, N, N’, N’- Tetramethylethylene Diamine (TEMED) as a polymerization assailant pair, 10% span 80 as a foam stabilizer were used. The gaffed super porous hydrogel’s were peg by inchoate enormity, computation of plausible density, porosity, bunion studies, void fraction, mechanical strength and surface morphology muse. In bifold distilled water, SPHCs trot out appalling accretion in their stasis bunion capacity. PVA revamp the bruise characteristics in twain the swelling media. SPHCs disport enriched mechanical clout as the concentration of polyvinyl alcohol is elevated. SEM images precisely marked the formation of interconnected pore, capillary channels, and the cross-linked polyvinyl alcohol molecules were espied encompassing the ambit of pores. From the characterization it was proved that polyvinyl alcohol has the good swelling properties in the synthesis of super porous hydrogel based drug delivery systems.
P. K. Desu, P. V. Rao * and V. Kotra
Department of Pharmaceutical Chemistry, St. Mary’s Group of Institutions Guntur, Chebrolu (V&M), Guntur, Andhra Pradesh, India.
03 February, 2018
07 May, 2018
11 June, 2018
01 October, 2018