SYNTHESIS AND CYTOPROTECTIVE EFFICACY EVALUATION OF NEW DRDE-07 ANALOGUES AGAINST SULPHUR MUSTARD TOXICITYAbstract
Sulfur mustard is well known as toxic Chemical warfare agent and on contact with skin it produces blisters as well as systemic toxicity. In this study we have evaluated the efficacy of few analogues of S-2(2-amino-ethylamino) ethyl phenyls sulphide (DRDE-07) and a known radioprotector amifostine against SM induced toxicity in mouse. We have selected seven newly synthesized analogues of DRDE-07 for their protection against 2LD50 dose of SM. On the basis of their protective efficiency we further evaluated the selected compounds using biochemical markers. Hepatic biochemical and histological assays were carried out in liver of SM exposed animals on day 3 and day 7 post treatment. Among the seven analogues DRDE-07, DRDE-19 and DRDE-46 showed a significant reduction in hepatic malondialdehyde levels compared to SM exposed liver, besides restoring the liver GSH level. Treatment with amifostine was also effective in regulating these biochemical parameters, The results thus conclude that oral administration of amifostine, DRDE-07, DRDE-19 and DRDE-46 were effective as prophylactic agent for protecting SM toxicity, and DRDE-07 proved to be comparatively better then others.
Shikha Sharma*, Neeti Jain, Uma Pathak, S C Pant and R Vijayaraghavan
Department of Pharmaceutical Sciences, Hari Singh Gaur University , Sagar (M.P.), India
02 September, 2010
15 October, 2010
25 October, 2010
01 November, 2010