SYNTHESIS AND DOCKING STUDIES OF 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDE DERIVATIVESAbstract
A novel N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-pipear azinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide derivatives (6a-6d) and (8a-8b) were synthesized by coupling 2-[(6-chloro-2-methylpyrimidin-4ylamino]-N-(2-chloro-6-methylphenyl) thiazole-5-Carboxamide(3) with Piperazine derivatives(4,7) in butanol and DIPEA (Diisopropylethylamine) at 120ºC for 4-5hrs. All the synthesized compounds were characterized physically and elucidated by Infrared spectroscopy, Mass spectroscopy, 1H-NMR spectroscopic techniques. All the synthesized compounds were subjected to Molecular docking studies by using 2GQG as its PDB ID. Among all the compounds, 6a, 6b, 6d, 8c and 8b exhibit anticancer activity.
K. Hemalatha*, Nandakishore Agarwal and G. Buchappa
Pharmaceutical Chemistry Department, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, India
03 November, 2012
21 December, 2012
30 January, 2013
01 February, 2013