SYNTHESIS AND EVALUATION OF SOME ALDEHYDE DERIVATIVES OF 1, 4 DI-HYDRO PYRIDINE AND THEIR BIOLOGICAL EVALUVATIONAbstract
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, PNA, ONF, MND, PAH posses significant anti convulsant activity. However, all the compounds showed analgesic activity less than the reference standard. Anti bacterial activities of the compounds were evaluated against staphylococcus aureus and the zone of inhibition was measured as the parameter of activity. Amikacin, the standard showed a zone of inhibition of 18 mm out of 8 synthesized compounds only one PNN (Ia) compound showed an equal activity when compared with standard. In which (ONF, PAN) showed considerable anti bacterial activity. The remaining four compounds PNM, MNC, MNA, PAK showed moderate antibacterial activity. Anti bacterial activity of the compounds were evaluated against E. Coli and the zone of inhibition was measured as the parameter of activity. Amikacin, the standard showed a zone of inhibition of 17 mm. out of 8 synthesized compounds, compound PNM, PAH showed maximum high degree of anti bacterial activity. The remaining compounds PNC, ONF, MNA, PAN showed moderate anti bacterial activity. The anti fungal activities of the compounds were evaluated against Candida albicans using Ketaconazole as the standard compound. The activity of the compounds measured in terms of zone of inhibition ranged between 7 to 15 mm where the upper limit is lower than that of Ketaconazole (15 mm), the compound ONF showed high degree of anti fungal activity.
S Venkataraman*, Anitha, R Meera, P Muthumani, R Xavier Arullapa, P Devi and N Chidambaranathan
Department of Pharmaceutical Chemistry, K M College of Pharmacy, Uthangudi, Madurai, TamilNadu, India
10 May, 2010
13 July, 2010
14 August, 2010
01 September, 2010