SYNTHESIS AND IN VITRO ANTIPLAQUE ACTIVITY OF CHALCONE, FLAVONOL AND FLAVANOL DERIVATIVES
AbstractSynthesis of chalcone derivatives was carried out by aldol condensation, these 2’-hydroxychalcones were cyclized to 3-hydroxyflavone and 2, 3- dihydroflavan-3-ol derivatives and we also report here there in vitro antiplaque activity. Most of the synthesized compounds were found to be active against Streptococcus mutans. Activity of two 3-hydroxyflavones was found to be higher than that of their corresponding 2, 3- dihydroflavan-3-ol derivatives and chalcone analogues. Investigated compounds having hydroxy group substituents in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antiplaque activity.
Article Information
63
5006-5014
994
1825
English
Ijpsr
Vijayalaxmi Chavan Patil
Government College of Pharmacy, Aurangabad-431005, Maharashtra, India
vijayalaxmi.pharma@gmail.com
31 August, 2012
15 October, 2012
30 November, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(12).5006-14
01 December, 2012
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