SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF SUBSTITUTED-2, 3-DIMETHYL-N-(3-(4-PHENYL PIPERAZIN-1-YL) PROPYL)-6, 7-DIHYDRO-5H-BENZO  ANNULENE-8-CARBOXYLIC ACIDSAbstract
Benzosuberones and phenylpiperazinyl moieties are important heterocyclic compounds which constitute many biological activities which include anti bacterial, anti fungal, anti inflammatory, antioxidant, antitubercular and anti cancer activities. A novel series of 2,3-dimethyl-N-(3-(4-phenyl piperazin-1-yl)propyl)-6,7-dihydro-5H-benzo annulene-8-carboxylic acids (5a-e) have been synthesized in good to excellent yields by experimental simplicity and milder reaction conditions and evaluated for their anti-proliferative activity. The titled compounds were identified and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. The novel derivatives synthesized were evaluated for in-vitro anti-proliferative activities on four different human cancer cell lines He La (cervical), MIAPACA (pancreatic), MDA-MB-231 (breast) and IMR32 (neuroblastoma) by sulphorhodamine B assay method. These synthesized novel derivatives which showed excellent anti-proliferative activity. The obtained results suggest that these classes of compounds can be considered as new hits for further structural optimization to obtain better anti-proliferative drug development program.
K. Vijay * and C. B. P. Devi
Department of Chemistry, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India.
25 January, 2018
12 April, 2018
27 April, 2018
01 October, 2018