SYNTHESIS AND MOLECULAR DOCKING STUDY OF BIOACTIVE QUINOLINO- BENZIMIDAZOLE DERIVATIVESAbstract
A series of some quinolino-benzimidazole/thiazole derivatives (3a-3h) have been synthesized from2-hydroxyquinoline-3-formaldehyde derivatives (1a-1d) and 1, 2-phenylenediamines/2-aminothiophenols (2a-2c). The synthesized compounds were characterized by FTIR, 1H-NMR and Mass Spectrometry. All the compounds were screened in-vitro for their antibacterial activity against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294. Among the compounds tested, compounds 3e showed potent antitubercular activity against M. tuberculosis at MIC 6.25 µg/mL. We extended our study to explore the inhibition mechanism by conducting molecular docking analysis by using Schrödinger.
N. J. Deshmukh, J. T. Deshmukh * and M. C. Mandewale
Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai, India.
05 April 2019
22 July 2019
13 August 2019
01 January 2020