SYNTHESIS AND PHARMACOLOGICAL ACTIVITY EVALUATION OF OXADIAZOLES CONTAINING SUBSTITUTED DIHYDROPYRIMIDINONE AND CHLOROQUINOLINE MOITIESAbstract
In the present paper, synthesis of new series of 1,3,4- oxadiazole derivatives incorporating substituted dihydropyrimidinone and chloroquinoline moieties 4(a-j) has been reported. All the synthesized compounds were characterized by FTIR, 1H NMR and Mass spectroscopy. The compounds were screened for their in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against some gram positive and gram negative strains of bacteria. This pharmacological activity evaluation revealed that among all the compounds screened, compounds 4c, 4e and 4g were found to have promising anti-inflammatory activity. Moreover, compounds 4b, 4c, 4d, 4g and 4j exhibited promising anti-bacterial activity against the selected pathogenic strains of bacteria.
Ambareen Shaikh* and Jyotsna Meshram
Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
15 July, 2013
20 August, 2013
17 November, 2013
01 December 2013