SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 2-SUBSTITUTED BENZOTHIAZOLE DITHIOMIDOCARBONATE DERIVATIVESAbstract
A series of novel 2- substituted benzothiazole dithiomidocarbonate derivatives were synthesized by the reaction of 2-amino benzothiazole with various halides. The test compounds were screened for their antimicrobial activity (antibacterial and antifungal) by disc diffusion method and the results of the microbial activity indicates that the test compounds exhibited varying degree of antimicrobial activity. Among the substituents benzyl moiety exhibited the most potent activity and the compound Dibenzyl (1,3 benzothiazo-2yl) Dithioimidocarbonate(4T1) emerged as the most active antimicrobial agent and it is equipotent when compared to the reference standard Ciprofloxacin. Among the substituents propyl moiety exhibited the most potent activity and the compound Dipropyl (1,3 benzothiazo-2yl) Dithioimidocarbonate (4T3) emerged as the most active antifungal agent and it is equipotent when compared to the reference standard Fluconazole.
Department of Pharmaceutical Chemistry, School of Pharmacy, Deccan Group of Institutions, Aghapura, Nampally, Hyderabad, Telangana, India
08 March, 2015
18 April, 2015
21 June, 2015
01 September, 2015