SYNTHESIS AND STUDY OF ANALGESIC, ANTI-INFLAMMATORY ACTIVITIES OF BIS (INDOLYL) METHANES (BIMs)Abstract
Gastro-intestinal (GI) toxicity is the common adverse effect which has been associated with most of NSAIDs available in the market. So the search for new therapeutic agents with high margin of safety and freedom from normally associated GI toxic effects has been a priority of pharmacologists and pharmaceutical industries. There are virtually limitless series of structurally novel heterocyclic compounds with a wide range of physical, chemical and biological properties. Literature survey reveals that coupling of two or more biodynamic molecules resulted in the enhanced biological activity. The present work embodied here involves synthesis and evaluation of analgesic and anti-inflammatory activities of some bis (indolyl) methane derivatives.
Partha Pratim Kaishap*, Chandrajit Dohutia and Dipak Chetia
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786 004, Assam, India
05 July, 2012
10 August, 2012
20 October, 2012