SYNTHESIS AND TESTING OF METAL COMPLEXES OF QUINOXALINE BASED SCHIFF BASES FOR ANTIMICROBIAL AND ANTICANCER ACTIVITIES

The compound 3-chloro-2-hydrazine quinoxaline was condensed with 2-furaldehyde to derive a Schiff base 2-furaldehyde-2-(3-chloro-2-quinoxalinyl) hydrazone (FCCQH).The ligand and also its complexes with VO (IV), Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Zn (II), and Pd (II) have been synthesized and characterized by elemental analysis, magnetic studies, thermal analysis, infrared spectra, UV-visible spectroscopy and Electron Spin Resonance data. The ligand 2-furaldehyde-2-(3-chloro-2-quinoxalinyl) hydrazone [FCCQH] acts as a neutral, bidentate one towards VO(IV), Zn(II), and Pd(II) coordinating through free C=N nitrogen and oxygen of furan ring and as tridentate one towards Cr(III), Mn(II), Fe(III), Co(II), and Ni(II) complexes coordinating additionally through nitrogen of quinoxaline ring C=N. The complexes have been screened for antibacterial activity towards staphylococcus aureus (gram +ve), Escherichia coli (gram -ve) bacteria, antifungal activity towards fusarium oxysporum and anticancer activities of the compounds were evaluated by MTT assay on HeLa (cervical cancer) cell lines. While the antimicrobial activity profiles of the complexes are, by and large quite encouraging, the anticancer activity exhibited by Ni (II) and Pd (II) complexes are highly impressive