SYNTHESIS, ANTIBACTERIAL ACTIVITY AND MOLECULAR PROPERTIES PREDICTION OF SOME PYRIDAZIN-3-ONE DERIVATIVESAbstract
We have synthesized some new pyridazine-3-one derivatives and characterized by means of IR, NMR & mass spectral data. Compounds were evaluated for in-vitro antibacterial activity by disc diffusion method and further subjected to molecular properties prediction and drug-likeness by Molinspiration software. All compounds were found in compliance with Lipinski ‘Rule of Five’ and presented a good drug-likeness score with no violations. Compound I and IV having substitutent (6-phenyl, 6-chloro phenyl) has documented good antibacterial activity against S. aureus & S. epidermidis. Compound III & V (4’-chloro-benzylidine, 4’-methoxy-benzylidine)has reported good activity against P. aeruginosa & E. coli.
Pankaj Budhlakoti , Y. Kumar , Amita Verma* and Shashi Alok
Head, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences-Deemed University, Allahabad, Uttar Pradesh, India
25 December, 2012
21 January, 2013
29 March, 2013
01 April, 2013