SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL SUBSTITUTED CIS-STILBENE DERIVATIVES
AbstractIn the present study, novel derivatives of substituted cis-stilbene were prepared from benzyl (chloro) triphenyl phosphorane, substituted phenyl acetic acid and In vivo anti-inflammatory activity was evaluated by carrageenan- induced rat paw edema assay model. The newly synthesized compounds were characterized by IR, 1H NMR and Mass analyses. The results revealed that all the test compounds protected the rats from carrageenan induced inflammation and the test compounds showed a significant anti-inflammatory activity against the control group. Among the compounds tested 1i, 1l, 1o, 2c, 2d, 2h, 3b and 3d showed better anti-inflammatory activity and 2f, 3c showed moderate activity.
Article Information
46
1982-1993
464KB
1429
English
IJPSR
Nilesh Jain*, Sarita Singhal and Surendra Kumar Jain
Research Scholar, Department of Pharmacy, Mahatma Jyoti Rao Phoole University, NH-8 near Achrol, Jaipur-302019, Rajasthan, India
nilujain01@yahoo.co.in
31 January, 2013
21 April, 2013
29 April, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(5).1982-93
01 May, 2013
Download