SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITIES OF SOME METAL COMPLEXES WITH SCHIFF BASE DERIVED FROM SUBSTITUTED SALICYLALDEHYDE AND AMINO ACIDSAbstract
The development of anti-microbial agents, microorganisms that have acquired resistance to drugs through a variety of mechanisms, have emerged and continue to plague human beings. Since, the use of anti-microbial drugs has selected drug-resistant bacteria, the proper use of currently available anti-microbial drugs and efforts to minimize the transmission and spread of resistant bacteria through appropriate infection control would be the first step in resolving the issue of resistant organisms. Synthesize and characterize some metal complexes with Schiff base derived from substituted salicylaldehyde and amino acids by an efficient methodology. The synthesized compounds were evaluated for their in-vitro anti-microbial activity. Synthesized compounds were examined for Anti-bacterial activity using the disc diffusion method and antifungal activity using cup plate method. The bacterial strains of Escherichia coli [Gram negative] MTCC – 443, Staphyloco ccusaureus [Gram positive] MTCC – 96, Bacillus subtilis, and Salmonella typhi using norfloxacin as standard. The fungal strain of Candida albicans with fluconazole was used as standard. In-vitro anti-microbial data represent the cobalt-containing metal complex were most active anti-bacterial compound, and the glutamine with zinc, serine with ferric complex were most active anti-fungal agents, its safe as its MIC value is much lower than the cytotoxic value. All the complexes synthesized may be stable at room temperature and non-hygroscopic in nature. The transition metal complexes of Schiff base ligands might have increased biological activities due to their lipophilic character.
Munusamy Jambulingam, Subramaniam Ananda Thangadurai * and Manickam Vijayabaskaran
Department of Pharmaceutical Chemistry, J. K. K. Nattraja College of Pharmacy, Komarapalayam Salem, Tamil Nadu, India.
22 May 2021
14 July 2021
16 July 2021
01 September 2021