SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW SUBSTITUTED IMIDAZOLESAbstract
In the present study, a new series of 2, 4, 5- trisubstituted imidazoles derivatives were synthesized taking different aldehydes as substitutions. The preliminary characterization of synthesized compounds identified by physical constants determination and TLC. The chemical structures were confirmed by means of IR, 1H-NMR and Mass spectral data. The synthesized compounds were screened for their anti-microbial and antifungal activity using standard methods. Both gram positive and gram negative organisms such as E.coli, B.subtilis, S.aureus, A. niger, C.albicans were used. The compounds screened for their antibacterial and antifungal activities A1, A2, A4 have shown promising antibacterial and antifungal activity against as compared to standard drugs Ciprofloxacin and Griseofulvin. The compounds were also screened for their antidepressant activities using forced swimming test in mice in which A1, A2 and A6 are found to be most significant while compounds A4 and A5 showed moderate activity as compared to standard drug Fluoxetin. The compound A4, 4-(4, 5-diphenyl-1H-imidazole-2-yl) phenol exhibited excellent activity.
R. Rambabu, J. Subbarao,* and P. Pavan Kumar
Department of Pharmaceutical Chemistry, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, A.P., India
27 August, 2014
29 November, 2014
27 December, 2014
01 April, 2015