SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH SCHIFF BASE (E)-4-[(HYDROXYL PHENYLIMINO)METHYL]BENZENE-1, 2-DIOLAbstract
Schiff base ligand (E)-4-[(hydroxyl phenylimino)methyl]benzene-1, 2-diol (H3L) was prepared from the condensation reaction of Protochatechu aldehyde (3, 4-dihydroxybenzaldhyde) with 2-amino phenol. From the direct reaction of the ligand (H3L) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II) nitrates in 2M:1L molar ratio, the five new neutral complexes were prepared. The characterization of the newly formed compounds was done by 1HNMR, UV-Vis and IR spectroscopy and elemental analysis. The in-vitro antibacterial activity and antifungal activity of the metal complexes were studied and compared with that of free ligand. The Cupper complex shows the higher biological activity.
A.M. Hassan, A.M. Nassar*, Y.Z. Ahmed and A.N. Elkmash
Chemistry Department, Alazhar University, Faculty of Science (Boys), Nasr city, Cairo, Egypt
15 March, 2012
01 May, 2012
22 June, 2012
01 July 2012