EVALUATION OF ANTIDIABETIC ACTIVITY OF POLYHERBAL FORMULATION AGAINST STREPTOZOCIN –NICOTINAMIDE INDUCED DIABETES IN RATSAbstract
The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using Streptozocin -nicotinamide in normal Albino wistar rats and study the antidiabetic activity of polyherbal formulation by comparison of changes in body weight and levels of glucose between normal and diabetic rats. Hypoglycemic agents from natural and synthetic sources are available for treatment of diabetes. Indian medicinal plants have been found to be useful to successfully manage diabetes. The effect of alcoholic extract of poly herbal preparation containing leaves of Gymnema sylvestre, fruits of Momordica charantia, rhizomes of Curcuma longa, seeds of Eugenia jambolana and fruits of Embilica officinalis was investigated in normal, glucose load conditions and streptozocin -nicotinamide induced diabetic rats. Significant anti diabetic activity was exhibited by the poly herbal formulation. Treatment with the polyherbal Preparation 200 mg/kg body wt and 400 mg/kg body wt for 10 days in diabetic animals has shown significant decrease in serum glucose levels in comparison to control animals.