SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL CARBAZOLE BORONIC ACID DERIVATIVES IN THE TREATMENT OF BREAST CANCERAbstract
The present study aimed to synthesize Carbazole boronic acid derivatives and determine their efficacy in treating breast cancer using the MCF-7 cell line. Nine different derivatives (C1-C12) of boronic acid were prepared i.e. 9-ethyl-(9H-carbazol-3-yl)-boronic acid (C1); (9-benzyl-9H-carbazol-3-yl)-boronic acid (C2); [9-(4-fluorobenzyl)-9H-carbazol-3-yl]-boronic acid (C3); [9-(sec-butyl)-9H-carbazol-3-yl]-boronic acid (C4); (9-pentyl-9H-carbazol-3-yl)-boronic acid (C5); (9-octyl-9H-carbazol-3-yl)-boronic acid (C6); (9-cyclopentyl-9H-carbazol-3-yl)-boronic acid (C7); [9-(4-chlorobenzyl)-9H-carbazol-3-yl)-boronic acid (C8); and [9-(2,4-dichlorobenzyl)-9H-carbazol-3-yl)-boronic acid (C9). Results showed that C3, C7, C8 and C9 exhibited more than 90% inhibition of cancer cell growth in MCF-7 breast cancer cell line. The percentage yield of these compounds was 20%, 26%, 24% and 24%, respectively. However, other compounds have also shown good anticancer properties compared to the control group. Thus, these compounds have shown potential in in-vitro studies and can be used as an anticancer drugs after pre-clinical and clinical studies.
Seema Chahar Beniwal and Tarun Virmani *
School of Pharmaceutical Sciences, M. V. N. University, Palwal, Haryana, India.
02 August 2022
25 February 2023
20 March 2023
01 April 2023