SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTICANCER EVALUATION OF BIS-[1,5]-BENZOTHIAZEPINES AGAINST HUMAN BREAST CANCER CELL LINE MCF-7Abstract
Bis-[1,5]-benzothiazepines (3a-i) containing two 1,5-benzothiazepine nuclei in a single molecule were synthesized by cyclocondensation reaction of bis-chalcones (1a-i) with two equivalent of 2-aminobenzenethiol (2). All the synthesized compounds were characterized by IR, 1H NMR,13C NMR and mass spectral analysis. Anticancer activity of the synthesized compounds against human breast cancer cell line MCF-7 was determined and the compound (3c) showed significant activity comparable to 5-fluorouracil.
R. N. Deshmukh and R. V. Dengle *
Department of Chemistry, Vivekanand College, Kolhapur, Maharashtra, India
15 June, 2016
19 August, 2016
13 September, 2016
01 December, 2016