SYNTHESIS, CHARACTERIZATION AND STUDY OF ANTIMICROBIAL ACTIVITY OF 2-HYDROXY 3-NITRO-5-METHYL-N-(SUBSTITUTED PHENYL) CHALCONE IMINESAbstract
Chalcones and its derivatives show various biological activities. The present study deals with the synthesis of series of 2-hydroxy-3-nitro-5-methyl–N-substituted phenyl chalcone imines from 2-hydroxy-3-nitro-5-methylphenyl chalcone and different substituted aromatic animes in ethanol in presence of 2, 3 drops of Conc. H2SO4. Structures of synthesized compounds have been established by spectral (IR, NMR, etc.) and elemental analysis. In the present communication we report the synthesis substituted chalcone imines and its antimicrobial activity against pathogenic bacteria and fungi. The sensitivity carried out by disc diffusion method displayed significant antimicrobial activity.
S. B. Borul * and S. V. Agarkar
Department of Chemistry, Late Ku. Durga K. Banmeru Science College, Lonar, Dist- Buldana (M.S.) India
07 December, 2014
08 February, 2015
26 April, 2015
01 August, 2015