SYNTHESIS, CHARACTERIZATION OF NOVEL MIXED METAL TARTRATEC OMPLEXES AND STUDY OF THEIR IN VITRO ANTIMICROBIAL ACTIVITY
AbstractA series of six new mixed metal complexes of general formulation [MM12(L)n]xH2O, where M= Mn, Co, Ni, Cu, Zn, Cd,M1=Fe, L= Tartrate ligand, x=1,5,6 and n = 3, are synthesized using tartrate as a bidented ligand. The newly synthesized complexes were characterized using various analytical techniques such as IR, XRD, TGA, Elemental analysis, magnetic susceptibility study etc. IR spectral data suggested that the bidentate ligand has coordination to both the metal ions through oxygen as donor atoms. The thermal behavior (TGA) of the complexes was studied; suggest the decomposition patterns were in good agreement with recommended formulae of the complexes. XRD technique revealed the presence of crystalline nature of all the studied complexes. The antibacterial activity of the metal complexes along with ligand was assayed against three bacterial pathogens viz. Bacillus Megatherium, Staphylococcus aureus, E-Coli, Pseudomonas and Proteus Vulgaris by well diffusion method. The bioassays of all the metal complexes showed a greater inhibitory effect in the form of broad activity spectrum than the individual ligand, which indicate an increased antimicrobial activity after the coordination
Article Information
19
1524-34
1244
1462
English
IJPSR
C. S. Patil *, N. S. Dhavale , V. B. Tadke and R. P. Pawar
Department of Chemistry, Deogiri College, Aurangabad, Maharashtra, India
chabu251962@yahoo.co.in
12 October, 2015
24 November, 2015
16 January, 2016
10.13040/IJPSR.0975-8232.7(4).1524-34
01 April, 2016