SYNTHESIS, CHARACTERIZATION, PHARMACOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF NOVEL BENZOXAZINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATIONAbstract
An attempt has been made to synthesize Benzoxazines and conduct Molecular docking studies of the same using Cyclooxygenase-1. All the synthesized compounds are then tested for anti-inflammatory activity by using fresh egg-white induced Paw edema method. The synthesis of novel Benzoxazine derivatives has been achieved by the reaction of Salicylaldehyde with Para Amino Benzoic Acid (PABA), which affords a Schiff base. The Schiff base on reduction with Sodium borohydride yields a reduced Schiff base which on cyclization with different aldehydes gives different substituted Benzoxazine derivatives. All the synthesized compounds are spectrally characterized by Infra-red, Mass, and 1HNMR spectroscopic techniques. The paw volume of the rat is measured with Plethysmometer. The % inhibition of paw thickness is calculated using the formula [% inhibition = (control-test)/control × 100]. All the synthesized compounds exhibited anti-inflammatory activity.
G. N. Kumar *, N. S. Subramanian, M. R. Devi, P. Harathi, N. S. Latha, G. Thapaswini and N. Ravikanth
Teegala Krishna Reddy College of Pharmacy, Meerpet, Saroor nagar, Ranga Reddy, Andhra Pradesh, India.
20 February 2014
17 April 2014
25 May 2014
01 September 2014