SYNTHESIS, CHARACTERIZATIONS AND ANTIMICROBIAL ACTIVITY OF NEW AURONE DERIVATIVES
AbstractAurones constitute a less studied sub-class of flavonoides which occur rarely in nature. Aurones are responsible for the golden yellow colour of some flowers. Substituted 2-benzylidene-1-benzofuran-3 (2H)-ones are commonly known as aurones that belong to the naturally occurring flavonoids. In the present investigation, a series of some novel substituted 2-benzylidene-1-benzofuran-3 (2H)-ones (2a-j) have been synthesized by cyclization of 1-(substituted-2-hydroxy-phenyl)-3-(4’-dimethylamino-phenyl)-prop-2-en-1-one (2-hydroxychalcone) (1a-j) with mercuric acetate in DMSO. The products were tested for purity by TLC and structures of newly synthesized compounds were confirmed by physical data, IR, 1H NMR and Mass spectral analysis. All these newly synthesized compounds were evaluated for their antibacterial activity against four different pathogens such as Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis and antifungal activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergillus flavus, using Peniciline and Greseofulvin as standard drugs by agar cup method and Poison plate method, respectively.
Article Information
12
733-738
549 KB
356
English
IJPSR
Madhav M. Kendre * and Ravi R. Vidule
Department of Chemistry, Shri Sant Gadge Maharaj Mahavidyalaya, Loha, Tq. Loha, Nanded, Maharashtra, India.
madhavkendre72@gmail.com
16 July 2023
10 October 2023
23 November 2023
10.13040/IJPSR.0975-8232.15(3).733-38
01 March 2023
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