SYNTHESIS, EVALUATION AND QSAR STUDIES OF SOME SUBSTITUTED PYRAZOLE DERIVATIVESAbstract
In the present paper QSAR studies related to some novel substituted pyrazole derivatives are reported. All the compounds were evaluated for antmicrobial activity viz- antifungal activity against A. niger. Their reported antimicrobial activities were used for Quantitative Structure Activity Relationship (QSAR) studies to find correlation between different calculated molecular descriptor of the compounds and biological activity. It is reported that five compounds viz. A-2, A-6, A-7, A-10 and A-11 showed maximum activity against A. niger.
Kishor Arora* and Veena Nathani
Department of Chemistry, Goverment P.G. College (Auto.), Datia (M. P.) India
22 October, 2015
09 December, 2015
22 January, 2016
01 April, 2016