SYNTHESIS, EXPERIMENTAL STUDIES OF THE ANTIMICROBIAL POTENTIAL OF SOME NOVEL 1, 5- BENZO THIAZEPINE DERIVATIVES
AbstractOptically active 1, 5- benzothiazepines belong to the well known benzothiazepine type substances. Some of them possess important bioactivities. In this article, optically active 2, 3-dihydro-1, 5-benzothiazepine derivatives are synthesized by the reaction of new α-β unsaturated carbonyl compounds with 2-aminothiophenol under mild conditions in the presence of silver sulphate in acetonitrile in short reaction time with excellent yield. The structures of newly synthesized compounds were confirmed by spectral evidence and the compounds were evaluated for their anti-bacterial and antifungal activity. All synthesized compounds have shown excellent results
Article Information
19
2619-2622
595
1309
English
Ijpsr
Asgar Jafar Khan* , Mohammad A. Baseer , Dhole J. M and S. Shah N
Laboratory of Organic Synthesis, Milliya College, Beed-431122, India
04 June, 2011
07 September, 2011
26 September, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(10).2619-22
01 October, 2011
Download