SYNTHESIS OF 4- (4-SUBSTITUTED)-1-(3- SUBSTITUTED- 5, 6-DIHYDRO- [1, 2, 4] TRIAZOLO [3, 4-A] PHTHALAZIN-6-YLAMINO) AZETIDIN-2-ONE DERIVATIVES AS ANTIDIABETIC AGENTSAbstract
In this research work, numerous molecules that have substituted triazole phthalazine derivatives were obtained using phthalic anhydride as a starting material. It was taken as starting material that gave reaction in the precence of different conditions with different substituted benzoyl chloride that yielded 6 chloro-3 substituted 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazine derivatives (I-V). These intermediates further reacted with substituted benzaldehyde and yielded 4-2-3-Substituted – 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazin-6-yl) substituted hydrazinyl derivatives (VI-X) which were further react with triethyl amine and acetyl chloride yields (XXI-XXX). The antidiabetic effect was investigated using oral glucose tolerance test in normal and non-insulin-dependent diabetes mellitus (NIDDM) in STZ-rat model. In this model Roziglitazone taken as a standard drug for this pharmacological activity.
Smita Singh *and Pranjal Kumar Singh
S. R. M. Modinagar College of Pharmacy, SRM Institute of Science and Technology, Delhi NCR Campus, Delhi Meerut Road, Modinagar, Uttar Pradesh, India.
11 January 2022
25 March 2022
26 April 2022
01 September 2022