SYNTHESIS OF BENZO[G]QUINOXALINE-5,10-DIONE BASED PYRAZOLINE DERIVATIVES AND THEIR ANTIMYCOBACTERIAL ACTIVITYAbstract
Eleven new compounds belonging to series 7-[5-(substituted) phenyl – 4, 5-dihydro-1H-pyrazol-3-yl]-2,3-diphenyl-5H, 10H – benzo[g] quinoxaline – 5, 10 – dione (Compound 7a-k) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv by L.J. Slope (Conventional) Method. Compound 7j having 4-CH3 at phenyl ring attached to 5-position of pyrazoline ring and compound 7i having 3,4-(OCH3)2 group on the above mentioned position have been observed as most and least active antimycobacterial compounds respectively.
S. Kumar *, N. Kumar and S. Drabu
Department of Pharmacy, Government Polytechnic, Uttawar, Palwal, Haryana, India.
14 May, 2017
23 July, 2017
25 July, 2017
01 February, 2018