SYNTHESIS OF N-(ALKYL OR ARYL)-2-(1H-BENZOTRIAZOL-1-YL)-ACETAMIDES AS SELECTIVE COX-2 INHIBITORAbstract
Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs and implementing GREEN chemistry. Arylacetamides are pharmaceutically interesting as they show various biological activities such as analgesic, local anesthetic, antiarthritic, antiarrhythmic activities, etc. In arylacetamides the nature of aromatic ring and its substituent is primary determinant for its activity. To serve this purpose, we have decided to substitute arylacetamide with benzotriazole which may exploit the analgesic potential of newly synthesized derivatives i.e N-(Alkyl or Aryl)-2-(1H-benzotriazol-1-yl)-acetamides and thus it may be helpful in reducing the pain without having side effect of ulcerogenicity.
Amruta Patil* and Gita Chaurasia
Mahatma Gandhi Vidya Mandir’s College of Pharmacy, Panchvati, Nashik, Maharashtra, India
24 June, 2013
30 July, 2013
25 October, 2013
01 November, 2013