SYNTHESIS OF NEW FLAVANOID AND CHALCONE DERIVATIVES AS ANTIMICROBIAL AGENT BY GREEN CHEMISTRY APPROACHAbstract
Flavanoids are plant secondary metabolites, synthesized by microwave assisted synthesis and green chemistry approach since, the conventional method of synthesis uses various organic solvents, hazardous by product, tedious work that requires more reaction time. Flavonoids have general structure of 15-carbon skeleton which consists of two phenyl ring (A and B) and heterocyclic pyran ring(C). Flavones are one of the important class of flavanoids acquires a broad spectrum of activity. Chalcone (1, 3-diaryl-2-propen-1-ones), is a privileged structure, demonstrating promising anti-microbial, anti-inflammatory and anticancer activities. The basic moiety of flavanoids gives numerous biological activities henceforth; flavanoid and chalcone derivatives were synthesized and confirmed by physiochemical and spectral data. Biological screening was done for antibacterial especially for anti-methicillin resistant Staphylococcus aureus and antifungal screening with using standard drug Ofloxacin and Griseofulvin respectively. Compound NKP-3, NKP-4, NKP-8a, NKP- 9a and NKP-10a are more active and other compounds are less active against bacteria and fungi.
Ashish Patel *, Ishan Panchal, Inaxi Parmar, Bharat Mishtry
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Parul University, Limda, Vadodara, Gujarat, India
25 November, 2016
17 January, 2017
02 February, 2017
01 June, 2017