SYNTHESIS OF NEW SERIES OF THIENYL ACRYLATE DERIVATIVES VIA BAYLIS-HILLMAN REACTION AND EVALUATION OF ANTIMICROBIAL ACTIVITYAbstract
A series of new Thienyl acrylate compounds were synthesized via Baylis-Hillman reaction and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a very good activity against Gram positive strains. The structure of these newly synthesized compounds were conformed by 1H NMR, IR, Mass and Elemental analysis, some of them were also confirmed by 13C NMR.
Anand Sivadas *, Maneesh Paul Satyaseela , Thirunavukkarasu Bharani , Sampath Kumar Upparapalli and Narayanan Subbaraya
Research Scientist-II, Department of Synthetic chemistry, Orchid Chemicals and pharmaceutical Ltd, Research and development, Shollinganallur, Chennai , Tamil Nadu, India
29 December, 2010
07 February, 2011
04 March, 2011
01 April, 2011