SYNTHESIS OF PHENYL HYDRAZINE SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITYAbstract
Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN’ disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and In- vitro anti-inflammatory activity.
VENKATARAMANA HS C., SINGH A., TIWARI A.*, TIWARI V.
Department of Pharmaceutical Chemistry, M. S. Ramaiah College of Pharmacy*, Bangalore, Karnataka, India
14 December, 2009
23 December, 2009
29 December, 2009
01 January, 2010