SYNTHESIS OF SOME N-HETROCYCLIC ANALOGS OF VASICINEAbstract
Vasicine is a pyrralazoquinazoline monobasic alkaloid obtained from the Plant Adhatoda vasica. In the present paper, the experiment were carried out to synthesis the various analogs of Vasicine, where the five membered ring C, was converted to seven membered ring, thus producing 7,8,9,10-Tetrahydroazepino[2,1-b] quinazolin-12(6H)one (RLX), was reported to be 6-10 times more potent than aminophylline as a bronchodilatory agent. A series of new compounds were synthesized, as modification in ring A and in ring B. The resulted compounds were evaluated for the antihistaminic activity to synthesis even more potent compounds.
N. MAHAJAN*1, K. L. DHAR, O. P SURI, K. NEPALI, N. KAMRA., A. GARG, A. SHARMA
Department of Pharmaceutical Sciences, Lovely School of Pharmaceutical Sciences, Lovely Professional University*, Phagwara, Punjab., India
06 January, 2010
25 January, 2010
28 January, 2010
01 February, 2010