SYNTHESIS OF THIAZOLIDINONE AND AZETIDINONE DERIVATIVES OF BENZOXAZOLINONE AS ANTIMICROBIAL AGENTSAbstract
The present investigation is concerned with synthesis of new substituted benzoxazolinone derivatives (1-18) with the objective of discovering novel and potent antimicrobial agents. The structure of all the synthesized compounds were elucidated by elemental (C, H, N) and spectral (IR, 1HNMR and mass) analysis. The purity of the synthesized compounds was checked by thin layer chromatography (TLC). The obtained compounds were screened for their antibacterial as well as antifungal activities and compared with reference drugs ciprofloxacin and fluconazole respectively. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, E. coli, K. pneumoniae and antifungal activity against A. niger, C. albicans. Compounds 13 and 18 were found to be the most potent members of the present series; they showed maxium antibacterial and antifungal properties much better than the standard drug. The compounds 15, 16 and 17 exhibited good antibacterial activity as well as while antifungal activity.
I. Singh * and A. Kumar
Department of Chemistry Janta Vedic College Baraut (Baghpat) U.P, India 250611
06 July, 2014
26 August, 2014
19 January, 2015
01 February, 2015