SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND PETRA OSIRIS MOLINSPIRATION (POM) ANALYSES OF DICARBOXYLIC ACID AMIDES

Six new Phthalic acid amides of the general formula  C8H5O3-NH-R  were prepared by the reaction of Phthalic anhydride with various amines namely Glycine, N, N-diphenyl amine, 1-naphthyl amine, 4-amino toluene-3-sulphonic acid, Toluene-p-sulphonamide, m-nitro aniline. The synthesized compounds were characterized by using   IR, 1HNMR & 13CNMR spectroscopy. Petra Osiris Molinspiration (POM) analyses revealed the significant bioactivity by elucidating the structural parameters in drug design of the synthesized compounds. In this work we have performed POM of our synthesized compounds to predict their drug like behaviour. Petra program package was used for the calculation of physiochemical properties of the organic compounds. On the basis of findings of Petra analyses reveals that our synthesized compounds have potential pharmacophores for antiviral and anti bacterial activities. Prediction of bioactivity by Molinspiration software calculates druglikeness score against GPCR ligands, ion channel modulators (ICM), kinase inhibitors (KI), nuclear receptor ligands (NRL), protease inhibitors (PI) and other enzyme inhibitors (EI). All synthesized compounds showed better activity against ICM, KI, PI and NRL as compared to the reference drug Ciprofloxacin which shows efficient binding to receptors and ion channels. The toxicity risk of synthesized compounds was checked by Orisis software online