SYNTHESYS AND SCREENING OF ANALGESIC ACTIVITY OF SOME NOVEL PYRAZOLEAbstract
The present study was aimed to study the analgesic potency of some new pyrazole compounds. Various Quinazolinone clubbed Pyrazole derivative compounds (7a1, 7a2, 7b1, 7b2) were synthesized by using anthranilic acid as starting material as per standard chemical procedure. The synthesized compounds were characterized by physical and spectral analysis by using UV-visible spectrophotometer, Fourier transform infra red (FTIR) Spectrophotometer, 1H Nuclear Magnetic Radiation spectrometer and Gas Chromatography Mass Spectophotometer.-QC-2010. Moreover Pyrazole derivatives have found their clinical application as analgesic agent. In this study the synthesized novel Pyrazole derivatives were screened for in-vivo analgesic properties by tail-flick method. The result obtained is compare with standard diclofenac. It has been observed that the maximum analgesic activity was recorded by the compound 7a1 having 359 % analgesic activity followed by compound 7b1 (268 %), 7b2(204 %) & 7a2 (159%) analgesic potential. The compounds 7a1showed nearly similar percentage analgesic activity compaired to standard drug Diclofenac sodium, whereas 7b1, 7b2 & 7a2 registered percentage analgesic activity relatively less than standard drug. The compound 7a1possess maximum analgesic potency.
Pratap Kumar Patra*, Ch. Niranjan Patra and Subasini Pattnaik
Associate professor, Department of Pharmaceutical Chemistry Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, R.R Dist. Hyderabad, Andhra Pradesh, India
04 December, 2013
17 January, 2014
09 March, 2014
01, May 2014