TASTE MASKING, DESIGN AND EVALUATION OF ORAL DISPERSIBLE TABLET OF ANTICHOLINESTERASE AGENTAbstract
This study aimed to determine for taste masking & design of Oro dispersible tablet of an anticholinesterase agent (Donepezil HCl) to achieve the patient compliance. Oral dispersible tablet prepared by compression method. The Anticholinergic activity assure by evaluation, drug dissolution, stability testing and standardize the oral dispersible tablet. On the basis of the preformulating and formulation study, the batch 10-F009 formulation would maintain stability and potency throughout the study period. Complete drug release was observed at gastric pH. Taste masking and rapid disintegration of tablets formulated in this investigation may possibly help in the administration of Donepezil HCL in a more palatable form without water. Finally, this formulation with once-daily dose is convenient for patients with the Alzheimer’s disease and related dementia with good therapeutic activity and bioavailability.
Md Juned Ad Javed Patel *, Surajkumar B. Rathod and Swapnali S. Mankar
Department of Pharmaceutics, Vardhaman College of Pharmacy, Koli, Karanja (Lad), Washim, Maharashtra, India.
25 January 2021
05 May 2021
28 May 2021
01 December 2021