TECHNICAL ADVANCEMENT IN BIODEGRADABLE POLYMERS AND THEIR RECENT PATENTSAbstract
The plethora of drug therapies and types of drugs demand different formulations, fabrications conditions and release kinetics. No single polymer can satisfy all the requirements. Therefore, there have been tremendous advances in area of biodegradable copolymers over the last 30 years. This article reviews current research on biodegradable polymers, focusing their potential as drug carries. The major classes of polymers are briefly discussed with regard to synthesis, properties and biodegradability, and known degradation modes and products are indicated based on studies reported in the literature. A vast majority of biodegradable polymers studied belongs to the polyester family, which includes polyglycolides and polylactides. Other degradable polymers such as polyorthoesters, polyanhydrides and polyphosphazenes are also discussed and their advantages and disadvantages are summarized.
T. Phale*, J. Agnihotri and A. Khale
Department of Pharmaceutics, H.K. College of Pharmacy, Mumbai-400102, Maharashtra, India
13 August, 2013
02 October, 2013
29 November, 2013
01 January, 2014