TERBINAFINE LOADED CHITOSAN SCAFFOLD FOR FUNGAL WOUND TREATMENTAbstract
Chitosan-based porous scaffolds are of great interest in biomedical applications especially in tissue engineering because of their excellent biocompatibility in vivo, good texture, surface contact, controllable degradation rate and tailorable mechanical properties. These days biomaterials scaffolds have contributed as an alternative choice of therapy mainly due to the increase failure rates in autografts and allografts techniques. Terbinafine HCl is allylamines group of drugs which is used topically to treat dermatophyte group of fungi like ringworm. Chitosan possesses both anti-bacterial and antifungal property which synergises with Terbinafine HCl (TBH) for both prophylactic and therapeutic actions in treating fungal wound infection (FWI). The haemostatic property of chitosan allows sorption of plasma, erythrocyte coagulation and platelets activation. These properties contribute additional role in repairing debilitated tissue. The prolong drug release property of fabricated scaffold and its natural characteristics of remodelling tissue favours its use in human fungal wound dressing. The main intention of this research work is to fabricate stable polymer medical devices, examine drug release profile and characterize TBH loaded CS porous scaffold with improved dual bioactivity against fungal wound infection. In the present research study it was observed that the fabricated scaffold had a prolonged drug release in compare to available conventional marketed cream, acceptable drug-polymer compatibility and hence can be projected that natural property of chitosan polymer favours synergistic effect in healing fungal wounded skin that attributed to sort out the problem of repeated use of drug application.
R. P. Yadav * and M. K. Chauhan
Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), New Delhi, India.
24 August 2019
05 February 2020
09 March 2020
01 August 2020