THE EFFECT OF ASPIRIN ON REPRODUCTIVE ORGANS OF FEMALE ALBINO RATAbstract
The aim of present investigation is to study the effect of oral administration of drug acetylsalicylic acid (ASA, aspirin) on female albino rat, Rattus norvegicus. The female rats (n=24) were allocated into 2 groups as control (n=12) and treated (n=12). The treated rats were given oral dose of aspirin 100 mg/ kg body weight for 15 days (n=6) and 30 days (n=6). Tissues enzymological estimations such as ACP (Acid Phosphatase) and ALP (Alkaline Phosphatase) along with histopathological studies of reproductive organs (ovary and uterus) were done. The present investigation indicated that, aspirin significantly increased ACP and ALP content in reproductive tissues and also caused significant histopathological variations in reproductive organs such as ovary and uterus by modulating certain enzyme metabolism in female albino rats.
Neha Jain, Renu Shrivastava, Arun K. Raghuwanshi and Vinoy K. Shrivastava*
Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal- 462026, Madhya Pradesh, India
24 April, 2012
14 May, 2012
21 July, 2012
01 August, 2012